Disease

Prostate Cancer

Overview of Prostate cancer

Prostate cancer forms in the prostate which is a small walnut-sized gland situated below the bladder and in front of the rectum in men and individuals assigned male at birth (AMAB). This gland produces a fluid that combines with semen helping maintain sperm health for conception and pregnancy.

Prostate cancer is a serious condition however, the majority of cases are detected before the cancer extends beyond the prostate. At this early stage treatment is often highly effective in eliminating the cancer.

How common is prostate cancer among men?

Prostate cancer is very common: It is one of the most frequently diagnosed cancers in men.
Mostly affects older men: The risk increases significantly after the age of 50.
1 in 8 men are affected: On average, about 1 in every 8 men will face a prostate cancer diagnosis in their lifetime.
A global concern: This cancer type is prevalent worldwide and affects millions of men.

Types of Prostate Cancer

Less common types of prostate cancer such as:

• Small cell carcinoma
• Transitional cell carcinoma
• Neuroendocrine tumors
• Sarcomas

Symptoms of Prostate Cancer

Prostate cancer in its early stages presents these symptoms:

• Frequent and sometimes urgent need to urinate, especially during the night
• Weak or interrupted urine flow
• Pain or burning sensation during urination (dysuria)
• Loss of bladder control (urinary incontinence)
• Loss of bowel control (fecal incontinence)
• Painful ejaculation and difficulty with erections (erectile dysfunction, or ED)
• Presence of blood in semen (hematospermia) or urine
• Pain in the lower back, hip, or chest

Causes of Prostate Cancer

• Age Factor: The risk of prostate cancer increases significantly as men age, particularly after 50 years of age.
• Family History: Men with a close relative (father, brother) who had prostate cancer are at a higher risk due to inherited genetic factors.
• Genetic Mutations: Changes in specific genes, such as BRCA1 and BRCA2, can raise the likelihood of developing prostate cancer.
• Hormonal Imbalance: High levels of testosterone or other male hormones (androgens) may promote the growth of prostate cancer cells.
• Dietary Habits: Consuming a diet high in red meat, processed foods, and dairy but low in fruits and vegetables may contribute to an increased risk.
• Obesity: Being overweight or obese is linked to a higher likelihood of aggressive or advanced prostate cancer.
• Ethnic Background: Prostate cancer is more common in men of African descent and less common in Asian men, suggesting genetic and environmental influences.
• Exposure to Chemicals: Long-term exposure to harmful chemicals, such as those found in certain pesticides, may raise the risk.
• Smoking and Alcohol Consumption: Smoking and excessive drinking can contribute to overall cancer risk, including prostate cancer.
• Inflammation or Infections: Chronic prostate inflammation or infections, like prostatitis, may be linked to a higher chance of developing cancer in the prostate.
• Lifestyle Choices: A sedentary lifestyle with limited physical activity might also increase susceptibility.

Complications in Prostate Cancer

• Urinary Issues: Difficulty urinating, weak flow, or frequent urination due to cancer growth or treatment effects.
• Erectile Dysfunction: Challenges with achieving or maintaining an erection caused by treatments like surgery or radiation.
• Cancer Spread (Metastasis): Cancer may spread to bones and organs, causing severe pain, fractures, or organ dysfunction.
• Bone Problems: Bone pain and fragility, increasing the risk of fractures when cancer reaches the bones.
• Bowel Discomfort: Radiation therapy may cause diarrhea, rectal pain, or bowel movement difficulties.
• Incontinence: Weak bladder control resulting in leakage or the need for pads or catheters.
• Fatigue and Weakness: Extreme tiredness due to cancer progression or treatment side effects.
• Infertility: Reduced ability to father children due to surgery or hormone therapy.
• Emotional Strain: Stress, anxiety, or depression as a result of coping with the disease.
• Swelling (Lymphedema): Swelling in the legs or groin if lymph nodes are affected or removed.

Risk Factors of Prostate Cancer

• Age: Risk increases after age 50 with higher chances as you get older.
• Family History: A history of prostate cancer in close relatives raises your risk.
• Ethnicity: African-American men are at higher risk and may develop it earlier.
• Genetics: If there are gene changes in your family, it can increase your risk.
• Diet: Diets rich in red meat and full-fat dairy may raise risk.
• Obesity: Being overweight or obese increases the likelihood of prostate cancer.
• Hormones: High testosterone levels can fuel cancer growth.
• Chemical Exposure: Exposure to harmful chemicals may raise your risk.
• Inflammation: Chronic prostate inflammation can increase the chances of developing cancer.

Preventions of Prostate Cancer

• Stay active and eat healthy: Regular exercise and a balanced diet rich in fruits, vegetables, and whole grains can support overall health and may lower your risk.
• Maintain a healthy weight: Obesity has been linked to a higher risk of aggressive prostate cancer, so keeping your weight in check can help.
• Limit high-fat and processed foods: Reducing red meat, fried foods, and processed snacks in your diet can make a positive impact.
• Know your family history: If prostate cancer runs in your family, talk to your doctor about starting screenings earlier.
• Regular check-ups are key: Routine health checks and prostate-specific antigen (PSA) tests can help detect changes early.
• Quit smoking and limit alcohol: These lifestyle changes not only benefit your prostate but improve your overall well-being.